When was the last time you were alone with your own thoughts?
Not scrolling. Not driving with a podcast on. Not "relaxing" with a show after the kids go to bed. I mean, actually alone. No noise. No input. No one needing anything from you.
Most of you can't remember.
And I get it. You've got a career. A family. A schedule that starts before dawn and ends when you collapse into bed. You are the person everyone counts on, the one who makes things happen. The one who holds it all together.
But while you've been holding it all together out there, something has been falling apart in here. Inside your skull. Quietly. For years.
Your brain is shrinking.
I know how that sounds. But I need you to hear it.
I have a client named Don. He's 87. One of the most impressive human beings I've met. Sharp businessman. Man of character. Productive. At 87, this guy is outworking people half his age.
Don came to us in Naples and did a full alpha plan. We scanned his entire body, including his brain.
What we found was not aging. It was disease.
Don's ventricles, the fluid spaces inside the brain, were enlarged. His sulci, the grooves on the surface of the brain, were wider than they should be. His hippocampus, the region responsible for memory, had shrunk. And scattered through his white matter were bright spots we call white matter hyperintensities.
Those bright spots are areas where Don's brain is dying.
Not might be dying. Is dying. Right now.
And here is what should make you angry. These changes have been reported on MRI scans for decades. Radiologists see them. They type up the report. And the report says "incidental findings without clinical significance."
Without clinical significance. Your brain is dying, and they call it incidental.
Several studies in the last ten years have blown that wide open. White matter hyperintensities are associated with brain atrophy, cognitive decline, stroke risk, gait disturbance, and vascular dementia. Every single one of those is serious. Some of them are devastating.
I shared something personal with the Alpha Maker community during this lecture. Of all the diseases I could get, a stroke is the one I fear most. I would take bone cancer. I would take kidney failure. I would take the worst infectious disease you can name.
But I do not want a stroke that robs me of my ability to recognize my wife. My children. The people I love most standing in front of me saying "Dad, I love you" and I have no idea what they're saying. Or worse, I don't know who they are.
That is what you're playing around with when you ignore what's happening inside your body.
Don fell the other day. He was getting up from a chair on his patio and went down. Hit his head. When I heard that, I winced. Because I know what brain shrinkage does.
As the brain gets smaller, the veins that connect the brain to the skull get stretched tight like a rubber band. They're called bridging veins. One good hit to the head and those veins can tear. Blood fills the space between the skull and the brain. Slowly. Over a day or two. It pushes the brain inward like a tumor.
That is the physical consequence of a brain that has been shrinking, unchecked, for decades.
And what causes the shrinking? What drives the white matter hyperintensities? What feeds the inflammation that eats away at your brain's small blood vessels, starves tissue of oxygen, and kills neurons?
Visceral fat.
Not cholesterol. Not "getting older." Visceral fat. The inflammatory fat packed around your organs that no doctor has bothered to measure.
Studies going back to 2017 show visceral adiposity is strongly correlated with white matter hyperintensities and brain volume loss. This isn't new science. It's been sitting there for almost a decade. Nobody talks about it. Nobody acts on it.
During this same lecture, I told the story of a man who came to our hospital. He was about 90, dressed in a suit, very polite, asking a doctor to sign a form saying he was safe to drive. The DMV required it. He thought he was fine.
Standing behind him was the young woman who drove him there. And she was shaking her head no.
That man had no idea how far gone he was. He thought he was healthy. He thought he could drive. His brain told him everything was fine because the part of his brain that would have told him otherwise had already deteriorated.
You think you'll be different?
Dr. Rosa, my colleague and one of the finest pathologists I know, has these same white matter changes in her own brain. She's in her 50s. She found them, and she was furious. Not because she has them. Because she knows what they mean, and she knows the medical system has been ignoring them.
She and I are building an Institute of Excellence for neurovascular imaging to attack this problem. Because nobody else is. We don't have funding. We don't have a big institution behind us. We're just going to do it.
Don doesn't have anything critically wrong yet. He caught it. And at 87 years old, this man is going to war on his own brain disease. He agreed to let me share his scans and his story publicly. Not to hide. Not to play it safe. To help you.
Do you have that kind of courage?
Are you going to sit alone with this information for five minutes and actually think about it? Or are you going to close this email, open your calendar, and go back to serving everyone else while your brain quietly dies?
I told you at the top. You never sit alone with your own thoughts.
Maybe you should start.
Not to meditate. Not for some wellness ritual. Sit alone so you can face what is happening inside you while you've been too busy to look.
Get an MRI. I don't care if you get it with me. Go do it on your own. Look at your visceral fat. Look at your brain. See what decades of stress, processed food, and ignoring the one body you were given have done.
Don did it at 87. Dr. Rosa did it in her 50s.
Your turn.
—Dr. Sean
Not Medical Advice: This newsletter is for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment, nor does it establish a doctor-patient relationship. The information provided should not be used as a substitute for consultation with qualified healthcare professionals. Always consult your physician before making changes to your diet, exercise, supplementation, or medication regimens. Individual results vary. The strategies discussed may not be appropriate for your specific situation. Never disregard professional medical advice or delay seeking it because of something you've read here. If you have existing health conditions or are taking medications, obtain medical clearance before implementing any protocols mentioned.
Always such excellent content, thank you! Finally getting mine next week. Looking forward to it with some trepidation but more excited to get a baseline and improve my lot in life going forward.
Hi Jerome, so sorry, just now seeing this. It took about 30-35 minutes and I should get results by mid to late next week. I've actually put ON weight since joining in here and it doesn't seem to be the good kind. I'm guessing it's connected to a new work and workout schedule, later getting home and later eating 3 concurrent nights every week, and, nightly 3:00 -4:00 am waking on top of that. Always diligent about circadian health so not sure what's going on there, but eager to nip this unexpected backslide in the bud. Looking forward to learning what doc says. Will let you know, thanks!